Moxey concedes he is "extremely disappointed" at Wolves' current position and the margin of their defeat by United saw them drop below Wigan on goal difference.
But he is adamant long-term goals for the club will not be "damaged" by a turbulent few weeks which saw the sacking of Mick McCarthy as manager and a series of poor results.
Moxey said: "In footballing terms we are, of course, extremely disappointed to be in the bottom three. We recognise that on the field results are the most important measure for any club.
"We are not happy with the current onfield situation, far from it, but we should put things into some sort of perspective.
"We shouldn't forget Wolves went through a period of spending just one season in the top division in 25 years.
"We are currently in our third consecutive season in the Premier League and still with every chance of going on to win our survival battle and make it four seasons."
Moxey added: "We remain optimistic, in the medium term at least, of maintaining the upward progress the club has enjoyed over the last six years or so. Off the field, we are in a strong position.
"We have a chairman in Steve Morgan whose passion and enthusiasm for Wolves is matched by his desire to make the club successful.
"We will not allow years of hard work put in by everyone to improve the club and achieve some long-awaited stability in the Premier League to be damaged by a few difficult and challenging weeks."