The Potters' 1-0 Barclays Premier League victory over Norwich at the Britannia Stadium was their 44th game this term.
A gruelling season has threatened to unravel recently, with the Staffordshire outfit losing four top-flight fixtures in a row and being eliminated from the Europa League at the first knock-out stage by Valencia.
Stoke have dug in, though, and ground results out again, winning three of their last four matches in all competitions.
That has included a 2-0 win at Crawley to secure an FA Cup quarter-final meeting with Liverpool, a home victory over Swansea in the league by the same scoreline and Saturday's triumph.
The Potters are back in the top half of the table and Pulis said: "I think what people don't appreciate is that that is 44 games we have played now.
"We got to the last 32 in Europe, we are in the quarter-finals of the FA Cup - we have had a really, really busy season in lots of respects.
"In the FA Cup, we will go to Liverpool and that is our fourth away game in that competition. It takes its toll and it is difficult.
"It is the first time this football club has been engaged in such a sequence of games, and we are talking about a top level against top sides, in Europe as well.
"It is draining, but what the players have done is get their heads down.
"They got a great result at Crawley - we went there and won with 10 men - and for that game, the Swansea game and now Norwich, the lads have really got their heads down and worked tremendously hard to get the results we want.
"We are sitting mid-table in the Premier League, had a great adventure in Europe and we still have the opportunity to go to Wembley."
Pulis was particularly pleased with Saturday's match-winner Matthew Etherington, who he feels is approaching his best form again.
"For Matty to score is good because it gives him that little bit of confidence," Pulis said.
"I think he goes a little bit up and down at times and mostly it is due to his confidence. So scoring will do him the world of good.
"Players, especially forward players, have good times and bad times and you have to ride with it.
"But Matty is a top, top player and he showed signs there of getting back to his best."
After Stoke had been frustrated in their efforts to break down some stubborn Norwich resistance, their 72nd-minute goal came in controversial circumstances.
Potters substitute Cameron Jerome headed Marc Wilson's throw-in - which replays suggested should have been awarded to the visitors instead - on to Etherington, who touched the ball past Elliott Ward before beating John Ruddy at the near post.
Canaries manager Paul Lambert was left fuming by the throw-in incident, although with regard to the actual goal, the Scot, whilst not wanting to be too hard on Ruddy, admitted the goalkeeper might have done a better job of trying to keep out Etherington's shot.
"I have spoken to John and he didn't need me to tell him - he knows," Lambert said.
"But I have to say, John Ruddy has produced some unbelievable moments for us and he will do it again, so I can't be too critical of him.
"He has been brilliant for me. He knows himself that maybe he shouldn't be beaten at his near post, but he has been colossal for us."