Manchester United leapfrogged Manchester City into first place after beating Liverpool 2-1 but City can go top again if they record at least a draw against Aston Villa.
Man City will be looking for good news as they should welcome back skipper Vincent Kompany after he recovered from the knee injury that kept him out of last week's match against Fulham.
In the early kickoff, 15th-placed West Brom travel to play an injury-hit Wolves, who are 17th in the table.
Wolves will be facing worries over the fitness of their central midfielders. Jamie O'Hara (groin) and Dave Edwards (thigh) are doubts for the derby showdown. Wolves are already without Emmanuel Frimpong, ho returned to Arsenal after rupturing knee ligaments, and the suspended Karl Henry in that department of his side.
Wolves: Hennessey, Foley, Johnson, Bassong, Ward, Doyle, O'Hara, Edwards, Jarvis, Ebanks-Blake, Fletcher.
West Brom: Foster; Reid, McAuley, Olsson, Ridgewell; Thomas, Mulumbu, Morrison, Scharner, Odemwingie; Fortune.
Aston Villa: Given; Hutton, Cuellar, Dunne, Collins; Petrov, Gardner; Albrighton, Keane, Heskey; Bent.
Man City: Hart; Zabaleta, Kompany, Lescott, Kolarov; De Jong, Barry; A Johnson, Silva, Milner; Aguero.
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Sunday's Premier League Fixtures
Wolves vs West Brom
Aston Villa vs Man City