Having beaten Chelsea 3-1 at Old Trafford earlier in the season, United will be looking to finally claim a victory on the blue side of London, something they have not been able to do since 2002.
With the team's 2-0 win over Stoke City coinciding with a Man City defeat by Everton, the Scot told Inside United he is well-aware of the importance of collecting three points this weekend.
"We’ve done very well away from home this season and we need to be good from now on," he said.
"We’ve got some really important away games in the run-in – Chelsea, Tottenham and City. They’re going to be crucial games."
Despite having faced great difficulty during recent away games against Chelsea, Sir Alex believes his players are ready for this Saturday's showdown.
"Games at Chelsea in the last few years have been tough and we’ve had terrible luck there which has caused us disappointing results," the manager shared.
"The players know what they need to do. They know their responsibilities and the standard and expectation at the club, and they have to carry those things with them when they go into games."