After back-to-back defeats in their opening two matches of the campaign, Spurs have found their form, winning fourteen of their last eighteen games to move level on points with United in third, three behind leaders City.
But while the likes of Scott Parker, Luka Modric and Gareth Bale have been stealing the spotlight this season, Spurs manager Harry Redknapp has backed academy product Jake Livermore to play a big role in their title challenge.
The 22-year-old shone in Wednesday's Barclays Premier League win over Everton and looks set to retain his place for Saturday's visit of Wolves after winning plaudits from his manager.
"You couldn't get a better lad than Jake," said Redknapp. "He's a fantastic boy with a great attitude and he's a really good player.
"If you had a club full of people like that you'd have a great club.
"When I first came people said he wouldn't make it at Tottenham - well Jake is good enough to play for anyone."
While Spurs push for the title, Wolves are battling at the other end of the table, but recent signing Eggert Jonsson believes their defensive resilience can stand them in good stead.
"We need to keep working hard to get clean sheets and if we can manage to do that and keep scoring goals, then hopefully we can turn some of our draws into wins," he said.
Also in the dogfight are Blackburn, whose manager Steve Kean has a goalkeeping dilemma this week with Paul Robinson's return to fitness ahead of their home game with Fulham.
Mark Bunn has excelled in the former England international's absence and Kean said: "He has made some fantastic saves and commanded his box well, so now we know we have two very good goalkeepers.
"Paul knows there is a goalkeeper breathing right down his neck who can deliver. It is a good problem to have."
Bolton go to Manchester United sitting just two points ahead of their basement-dwelling Lancashire rivals and with manager Owen Coyle calling for big performances from key men.
That could include out-of-favour club captain Kevin Davies after Coyle stated: "You need players with big hearts, that are brave enough to get on the ball, pass and move and who can go into arenas like Old Trafford and perform. Kevin is one of those."
West Brom sit five points above the bottom three in 15th and are looking to kick-start a push up the table against a Norwich team confounding expectations still more in ninth.
The Baggies then face Stoke, Fulham, Swansea, Wolves and Sunderland, and assistant head coach Keith Downing said: "You target games and think 'this is an opportunity to get three points'. I would think in this mini-league of 12 to 14 teams we are all able to beat each other.
"We are in agreement that it's six games where we could get away from that relegation zone or we could be dragged into it."
Elsewhere on Saturday, Aston Villa take on Everton, Sunderland go to Chelsea - where they produced a stunning 3-0 win last season - and Liverpool host Stoke.
Sunday sees Newcastle face QPR and Swansea play Arsenal, while Manchester City go to Wigan on Monday evening.
Saturday's Premier League Fixtures
Chelsea vs Sunderland
Man United vs Bolton
West Brom vs Norwich
Aston Villa vs Everton
Blackburn vs Fulham
Liverpool vs Stoke
Tottenham vs Wolves
Sunday's Premier League Fixtures
Newcastle vs QPR
Swansea vs Arsenal
Monday's Premier League Fixtures
Wigan vs Man City