United travel to Anfield next weekend for a fixture which is one of the most eagerly anticipated fixtures in the Barclays Premier League calendar.
Only last season, the Reds stormed to a 3-1 win in a match which saw Luis Suarez announce his arrival as a new Liverpool favourite after a masterclass performance, while also having its fair share of flashpoints.
Brazilian defender Rafael could have seen red for United after a dangerous lunge on Lucas, while Liverpool veteran Jamie Carragher's studs-up challenge on Nani left the Portuguese winger writhing in pain.
However, Clarke has played down the significance of next weekend's clash, insisiting the Reds will be approaching the game like any other.
Nonetheless, he did admit that preparations will be hampered due to the latest round of international matches.
"The preparations will be exactly the same [as any other match]. We don't get the full group to work with until the day before the game, which is disappointing but you just have to deal with it.
"It's not ideal because it [the match against United] comes on the back of an international break and we've only had five or six players left behind."
"Hopefully we'll have time on Friday to do a bit of team play and get them ready for the game, but it's a difficult situation.
"You just hope you get your players coming back fit and well, and you work on them mentally to make sure they're ready for such a big game."
Liverpool are currently fifth in the Premier League, six points behind table-topping United.