Saturday's early kickoff sees Liverpool travel to play Everton in a game which could see the return of Steven Gerrard to the Reds' starting lineup. The England international has featured sporadically since recovering from a groin injury, but owing to the magnitude of the fixture, could just be thrusted into the deep end by manager Kenny Dalglish.
On Sunday, Tottenham play hosts to Arsenal in the North London derby, where it will be interesting to see the kind of reception Emmanuel Adebayor gets from the travelling Gunners faithful. Having already incurred their wrath by running the length of the pitch to celebrate in front of them whilst playing at Manchester City, there is certainly no love lost between player and fans.
Elsewhere, City and local rivals Manchester United will look to bounce back from disappointing Champions League fixtures in midweek when they take on Blackburn and Norwich respectively.
Here, we take a look at all the news from the selection table.
Everton vs Liverpool
Liverpool captain Steven Gerrard may have to settle for a place on the bench again in Saturday's 216th Merseyside derby against Everton.
The England midfielder has played just 25 minutes after a six-month lay-off from a groin operation.
Defenders Glen Johnson (hamstring) and Daniel Agger (rib) will not feature - although the latter has returned to training - while forward Dirk Kuyt is pushing for a recall at the expense of Jordan Henderson.
Everton manager David Moyes believes Tim Cahill should be fit for the game.
Cahill sustained severe bruising to his shin after seemingly being stamped on by Vincent Kompany during the 2-0 defeat by Manchester City at the Etihad Stadium last weekend.
After simply doing light jogging on Thursday, according to Moyes, Cahill has trained more seriously on Friday, with the Scot hopeful he will be ready.
Everton (from): Howard, Heitinga, Hibbert, Neville, Distin, Jagielka, Baines, Barkley, Fellaini, Osman, Rodwell, Drenthe, Cahill, Stracqualursi, Mucha, Bilyaletdinov, Vellios, Gueye, Saha, Coleman.
Liverpool (from): Reina, Kelly, Carragher, Skrtel, Enrique, Lucas, Adam, Kuyt, Downing, Suarez, Carroll, Doni, Flanagan, Coates, Spearing, Gerrard, Henderson, Bellamy, Rodriguez.
Man United vs Norwich
Wayne Rooney, Javier Hernandez and Jonny Evans will all be back from injury for Manchester United when Norwich visit on Saturday.
Chris Smalling (groin), Nemanja Vidic (ankle) and Tom Cleverly (foot) are still missing but could return after the international break.
Norwich will be without striker James Vaughan as he is set to be out for up to four months with a knee injury.
Centre-back Zak Whitbread is still recovering from his hamstring problem, while on-loan United defender Ritchie de Laet is unavailable against his parent club.
Defenders Elliott Ward and Dani Ayala (both knee) remain out, while young midfielder Korey Smith is set for a spell on the sidelines after ankle surgery.
Manchester United (from): De Gea, Lindegaard, Evans, Evra, Fabio, Jones, Ferdinand, Anderson, Carrick, Fletcher, Giggs, Nani, Park, Valencia, Young, Berbatov, Hernandez, Owen, Rooney, Welbeck.
Norwich (from): Ruddy, Tierney, Barnett, R Martin, Naughton, Fox, Johnson, Hoolahan, Pilkington, Bennett, Morison, Rudd, C Martin, Crofts, Holt, Francomb, Wilbraham, Drury.
Aston Villa vs Wigan
Wigan defender Emmerson Boyce is close to a recall to face Aston Villa having recovered from the hamstring problem which has kept him out of the last two league matches.
His return would be welcome as Steve Gohouri is suspended having been sent off against Tottenham last week.
Fellow defender Antolin Alcaraz (thigh) and striker Hugo Rodallega (knee) are unavailable.
On-loan Tottenham midfielder Jermaine Jenas is in contention to make his Aston Villa debut after recovering from a thigh problem.
Record signing Darren Bent has shaken off a groin injury while fellow striker Emile Heskey is also in the frame after a recent hamstring setback.
Villa boss Alex McLeish will give a late fitness test to defender James Collins who suffered an ankle knock against QPR last weekend. Carlos Cuellar, Chris Herd and Eric Lichaj remain sidelined.
Aston Villa (from): Given, Hutton, Collins, Dunne, Warnock, Jenas, Petrov, Delph, N'Zogbia, Ireland, Bannan, Agbonlahor, Bent, Heskey, Albrighton, Weimann, Given, Delfouneso, Beye, Lowry, Gardner, Clark.
Wigan (from): Al Habsi, Caldwell, Figueroa, Boyce, Lopez, Watson, Diame, Moses, Gomez, Di Santo, Jones, Stam, Van Aanholt, McArthur, McCarthy, Thomas, Sammon, Maloney, Crusat, McManaman, Kirkland.
Blackburn vs Man City
Manchester City boss Roberto Mancini may give Edin Dzeko a starting role against Blackburn in the Barclays Premier League after the striker apologised for his angry reaction to being substituted against Bayern Munich in midweek.
With Carlos Tevez suspended by the club following his apparent refusal to come off the bench in Munich, the Bosnian is likely to partner Sergio Aguero in attack.
Nigel de Jong is likely to be on the bench again and though Adam Johnson is back in training after an ankle injury it may be to soon for him.
Blackburn manager Steve Kean is still waiting on the fitness of defenders Scott Dann and Michel Salgado.
Neither player has trained this week and the pair will undergo late tests to determine whether they will be able to face City at Ewood Park.
Martin Olsson is definitely out through suspension following his red card at Newcastle but Gael Givet has recovered from the knock he sustained at St James' Park and should be available, while Kean confirmed Ryan Nelson and David Dunn are edging closer to a return.
Blackburn (from): Robinson, Samba, Dann, Salgado, Givet, Hoilett, Lowe, Nzonzi, Formica, Yakubu, Bunn, Hanley, Grella, Pedersen, Petrovic, Rochina, Goodwillie, Roberts, Vukcevic, Slew.
Manchester City (from): Hart, Pantilimon, Richards, Onuoha, Kompany, K Toure, Savic, Lescott, Clichy, Kolarov, Bridge, De Jong, Barry, Milner, Y Toure, Nasri, Aguero, Silva, Zabaleta, Dzeko, Johnson.
Sunderland vs West Brom
West Brom central defender Gabriel Tamas is available for Saturday's Premier League clash with Sunderland at the Stadium Of Light after completing a three-game suspension.
But he faces a battle to regain his place following an impressive performance by summer signing Gareth McAuley in last weekend's goalless home draw with Fulham.
Defender Craig Dawson is expected to recover from the illness which meant he was unable to train on Thursday, but midfielder Zoltan Gera and striker Marc-Antoine Fortune are still sidelined through injury.
Sunderland defender Titus Bramble will miss out after being suspended by the club.
The 30-year-old will not train or play with his team-mates until an investigation into allegations of sexual assault and possession of a Class A drug has been completed.
Midfielder Sebastian Larsson has been playing after having pain-killing injections in a broken toe and his condition will be assessed, while striker Connor Wickham (groin) is a doubt and Craig Gordon and Fraizer Campbell (both knee) continue to work their way back to fitness.
Sunderland (from): Mignolet, Westwood, Brown, O'Shea, Richardson, Turner, Laing, Cattermole, Gardner, Vaughan, Larsson, Colback, Elmohamady, Bendtner, Sessegnon, Wickham, Ji, McClean, Cook.
West Brom (from): Foster, Reid, Tamas, Dawson, Olsson, McAuley, Shorey, Brunt, Dorrans, Mulumbu, Thomas, Long, Odemwingie, Morrison, Fulop, Jones, Cox, Scharner, Tchoyi.
Wolves vs Newcastle
Davide Santon will be included in the Newcastle squad for the first time for Saturday's Barclays Premier League trip to Wolves.
The 20-year-old Italian played 90 minutes for the reserves in midweek after having fluid drained from his knee and could make his senior debut at Molineux.
However, striker Shola Ameobi will miss out once again with a shoulder injury, while Alan Smith (hamstring) and Mike Williamson (broken arm) remain on the sidelines.
Defender Richard Stearman is Wolves' major new fitness doubt.
Stearman suffered a toe injury during the 2-1 defeat against Liverpool at Anfield and was substituted at half-time.
If he is ruled out, 19-year-old Matt Doherty will start against the Magpies.
Striker Steven Fletcher has recovered from the groin problem which restricted him to a second-half substitute's role against the Reds.
Jody Craddock, Ronald Zubar, Kevin Foley and Sylvan Ebanks-Blake are still unavailable through injury.
Wolves (from): Hennessey, Stearman, Johnson, Berra, Ward, Hunt, Henry, O'Hara, Jarvis, Edwards, Doyle, Doherty, Fletcher, Guedioura, De Vries, Elokobi, Hammill, Milijas.
Newcastle (from): Krul, Harper, Simpson, R. Taylor, Santon, Ferguson, Coloccini, S. Taylor, Tiote, Cabaye, Gutierrez, Marveaux, Obertan, Gosling, Guthrie, Ben Arfa, Abeid, Vuckic, Ba, Lovenkrands, Best, Sammy Ameobi.
Bolton vs Chelsea
Daniel Sturridge could return to the Chelsea line-up for Sunday's Barclays Premier League trip to Bolton.
The forward missed Saturday's win over Swansea with a knee injury and also sat out Wednesday night's Champions League draw at Valencia, but he is fit to return to the club where he spend the second half of last season on loan.
Fernando Torres starts a three-match ban, goalkeeping understudy Hilario is still a week or two away from recovering from a hip and back complaint, while Michael Essien (knee) is a long-term absentee.
Bolton manager Owen Coyle faces further selection issues ahead of the game.
Coyle is already without a number of long-term injured, with the casualty list compounded this week when it was announced midfielder Stuart Holden faces another six months on the sidelines with a knee problem.
To add to his woes, on-loan Gael Kakuta is ineligible as he cannot face his parent club, David Wheater and Ivan Klasnic are suspended, and goalkeeper Jussi Jaaskelainen is doubtful with a leg knock.
Bolton (from): Jaaskelainen, Steinsson, Cahill, Knight, Eagles, Robinson, Muamba, Reo-Coker, Petrov, K Davies, Tuncay, Bogdan, Gardner, M Davies, Pratley, Ngog, Blake.
Chelsea (from): Cech, Ivanovic, Bosingwa, Alex, Ferreira, Terry, Luiz, Cole, Bertrand, McEachran, Mikel, Romeu, Ramires, Lampard, Meireles, Mata, Malouda, Drogba, Anelka, Sturridge, Lukaku, Kalou, Turnbull.
Swansea vs Stoke
Stoke winger Matthew Etherington will undergo a fitness test ahead of the Potters' Barclays Premier League trip to Swansea on Sunday.
Etherington limped out of Thursday night's 2-1 Europa League Group E victory over Besiktas with a dead leg.
Defender Jonathan Woodgate is available again having missed that game because he is not part of Stoke's squad for Europe, and the rested Asmir Begovic is set to return in goal in place Thomas Sorensen.
Salif Diao (fractured cheekbone) is another injury doubt, while Kenwyne Jones (hamstring) is not expected to make his comeback until after the international break.
Midfielder Leon Britton is the major fitness concern for Swansea manager Brendan Rodgers.
Britton is still struggling with the back complaint that saw him withdrawn early against Chelsea last weekend but Rodgers is hopeful his playmaker will be available.
Striker Danny Graham could come back into the starting line-up in place of Leroy Lita but midfielder Ferrie Bodde is set to undergo yet another operation in the latest setback to his recovery from a series of knee injuries.
Garry Monk and Ashley Williams are again the only fit centre-halves with Alan Tate (broken leg), Steven Caulker (knee) and Kemy Agustien (hamstring) all sidelined.
Swansea (from): Vorm, Williams, Taylor, Britton, Graham, Sinclair, Dyer, Dobbie, Routledge, Monk, Lita, Moore, Bessone, Moreira, Rangel, Allen, Tremmel, Gower, Richards, Lucas.
Stoke (from): Begovic, Wilson, Huth, Shawcross, Upson, Wilkinson, Woodgate, Whelan, Whitehead, Etherington, Walters, Sorensen, Shotton, Arismendi, Pennant, Delap, Crouch, Palacios, Jerome, Nash.
Fulham vs QPR
QPR defender Armand Traore is supended for Sunday's west London derby at Fulham following his red card against Aston Villa last weekend.
Danny Gabbidon looks certain to miss out again with a knee injury picked up in Rangers' Barclays Premier League win over Wolves almost a fortnight ago, while the game comes soon for Jamie Mackie, who this week played in a friendly for the first time since suffering a double leg break in January.
Midfielder Kieron Dyer also remains sidelined with a foot problem.
Fulham forwards Bobby Zamora and Mousa Dembele are both available after recovering from illness.
The Cottagers will give Aaron Hughes (knee) a fitness test on Saturday and Matthew Briggs is also a doubt with a bruised ankle that he suffered in Thursday night's Europa League win against Odense.
Simon Davies remains sidelined by a long-term knee injury but Fulham boss Martin Jol said on Friday that he hopes the midfielder will be available for selection by November.
Fulham (from): Schwarzer, Hughes, Hangeland, Baird, J Riise, Kelly, Briggs, Sidwell, Duff, Kasami, Murphy, Dempsey, Dembele, Ruiz, Zamora, Etheridge, Senderos, Briggs, Grygera, Frei, Gecov, Sa, Johnson.
QPR (from): Kenny, Derry, Hall, Taarabt, Campbell, Bothroyd, Faurlin, Buzsaky, Orr, Connolly, Barton, Young, Smith, Helguson, Murphy, Wright-Phillips, Ferdinand, Puncheon.
Tottenham vs Arsenal
Tottenham manager Harry Redknapp will revert to his first-choice line-up for Sunday's north London derby, meaning Emmanuel Adebayor is in line to face his former club Arsenal at White Hart Lane.
Redknapp, who made 10 changes to his team for the Europa League win over Shamrock Rovers, will give Aaron Lennon a fitness test after he had to come off with a stiff groin on Thursday night.
William Gallas (calf), Michael Dawson (Achilles) and Tom Huddlestone (ankle) are out but Steven Pienaar is available to play his first game of the season after overcoming a groin problem.
Arsenal will give late fitness tests to Theo Walcott (knee) and Gervinho (hamstring) before the game but central defender Laurent Koscielny (ankle) is out.
Johan Djourou (hamstring) also remains out but Yossi Benayoun (thigh) and Sebastien Squillaci both return to the squad after training this weekend.
Midfielders Jack Wilshere and Abou Diaby plus defender Thomas Vermaelen continue their rehabilitation from ankle injuries.
Tottenham (from): Gomes, Friedel, Cudicini, Bale, Kaboul, Bassong, Corluka, Walker, King, Assou-Ekotto, Rose, Parker, Modric, Livermore, Townsend, Carroll, Lennon, Kranjcar, Rose, Falque, Sandro, Pienaar, Pavlyuchenko, Defoe, Dos Santos, Adebayor, Van der Vaart.
Arsenal (from): Szczesny, Sagna, Gibbs, Koscielny, Mertesacker, Song, Andre Santos, Frimpong, Arteta, Rosicky, Oxlade-Chamberlain, Ramsey, Arshavin, Gervinho, Benayoun, Squillaci, Chamakh, Walcott, van Persie, Fabianski, Park, Jenkinson, Coquelin.