Manchester United have made a blistering start to the Premier League season and sit top after winning their first four games and scoring 18 goals in the process, including an 8-2 demolition of Arsenal.
Chelsea have also made an unbeaten start, with 10 points from four matches, and would go above United with victory at Old Trafford on Sunday afternoon.
Former Porto manager Villas-Boas said: "We face United perhaps in their most tremendous moment of motivation and flair and style."
"We will go there to try to win it. Let's see how it happens. It's going to be a very, very good early-season game for the Premier League.''
John Terry and Frank Lampard should be back in the Chelsea line-up after being rested for their 2-0 Champions League win over Bayer Leverkusen, however Didier Drogba may miss out having not fully recovered from a head injury sustained against Norwich City.
For United, David De Gea will return in goal despite Anders Lindegaard's impressive performance in their 1-1 Champions League draw with Benfica. After the game in Portugal, Ferguson made it clear that he intended to restore his big-money summer capture.
"We were always going to share it and David will play on Sunday against Chelsea."
Wayne Rooney goes into the game aiming for a third consecutive Premier League hat-trick but, in contrast, his counterpart Fernando Torres will be looking to end a goal drought that has seen him score just one goal in 29 games for club and country.
Tottenham host Liverpool in the early kick-off on Sunday.
Spurs should be well-rested, with manager Harry Redknapp excusing a number of his first-teamers a Europa League clash against PAOK Salonika in midweek after describing the fixture as "a nuisance".
Liverpool, meanwhile, will be looking to bounce back after defeat away at Stoke last weekend - their first loss of the season.
On Saturday, Blackburn secured their first Premier League win of the season as they came from behind to stun Arsenal 4-3 at Ewood Park.
Swansea earned their first-ever Premier League win with a convincing 3-0 victory over West Brom as all three top-flight newcomers enjoyed victorious afternoons.
Elsewhere, Norwich beat Bolton 2-1 at the Reebok thanks to two first-half goals, securing their first league win of the campaign.
QPR beat Wolves 3-0 thanks to early goals from Joey Barton and Alejandro Faurlin and a late strike by DJ Campbell at Molineux.
Everton beat Wigan 3-1 at Goodison Park thanks to late goals from substitutes Apostolos Vellios and Royston Drenthe.
At Villa Park, the spoils were shared by Aston Villa and Newcastle in a tight 1-1 draw while Swansea ran away 3-0 winners against West Brom.
Tottenham vs Liverpool
Fulham vs Manchester City
Sunderland vs Stoke
Manchester United vs Chelsea
Blackburn R. 4-3 Arsenal
Aston Villa 1-1 Newcastle U.
Bolton W. 1-2 Norwich C.
Everton 3-1 Wigan Athletic
Swansea C. 3-0 West Bromwich A.
Wolverhampton W. 0-3 Queens Park R.