The pair have failed to recover from their respective knee injuries, leaving manager Roberto Mancini to consider his options for the trip to north London.
City have not beaten the Gunners away from home since 1975 but know victory this time would open a five-point gap on Arsene Wenger's men.
Arsenal have no fresh injury concerns.
Left-back Kieran Gibbs misses out but should be available for the weekend's FA Cup tie with Leeds after recovering from an ankle injury.
Midfielder Abou Diaby (calf), goalkeeper Manuel Almunia (ankle) and centre-back Thomas Vermaelen (Achilles) remain out.
Arsenal (from): Fabianski, Clichy, Djourou, Koscielny, Sagna, Fabregas, Walcott, Arshavin, Song, Nasri, Wilshere, Denilson, van Persie, Squillaci, Eboue, Bendtner, Szczesny, Rosicky.
Manchester City (from): Hart, Given, Zabaleta, Richards, Boateng, K Toure, Kompany, Boyata, Kolarov, Lescott, Bridge, Wright-Phillips, Johnson, De Jong, Vieira, Milner, Y Toure, Barry, Tevez, Adebayor, Jo.