The 22-year-old has been rewarded for a fine season with Claude Puel's side, putting in a number of outstanding performances in his 21 Premier League appearances.
Ward-Prowse is familiar with Three Lions boss Gareth Southgate, who worked with the youngster at Under-21 level, but making the step up to the senior team is the realisation of a "life-long" dream for the Saints youth product.
Over the moon to get my first senior England call up, can't wait for the games!! Congrats to Redderz too 👏🏻 pic.twitter.com/EwNLYc3vBy
— James Ward-Prowse (@Prowsey16) March 17, 2017
"It's obviously an incredibly proud feeling for me," he told reporters. "It's always been a life-long ambition and a career ambition to reach the senior squad.
"I think it's every young player's dream to play for England and to be given that opportunity and chance to represent your country and do everyone proud is a great honour.
"Should the chance come this week, I'll be ready to take it. I can't wait to draw every ounce of knowledge from other players who have been in the group before this week, to help me as a player as well."
Southgate's men take on the Germans in a friendly on Wednesday before locking horns with Lithuania in a World Cup qualifier on Sunday.