The Bluebirds head into the Barclays Premier League encounter at the Cardiff City Stadium in desperate need of points having won just one of their last 12 league games.
Last weekend's 1-0 defeat at Tottenham was their fourth straight loss and left Cardiff just one point and one place off Fulham, who lie at the foot of the standings.
Cardiff are three points adrift of 17th-placed West Brom, who hold the last position of safety.
"It's the biggest game for us," Solskjaer said to www.cardiffcityfc.co.uk.
"Obviously, this game is massive. You just want your players to go out there, play and express themselves with no fear."
Solskjaer expects a battle against a Fulham side that has failed to win since beating West Ham on January 1.
"At this stage of the campaign, you look at the form and confidence and I don't think any of these two teams can say we are in top shape," he said.
"I don't think either side would be happy with a draw. There will be two teams that have to go out there and try to win the game. I think you will see some positive football from both sides.
"But we are at home.
"We've played some good games at home lately even though the Hull game (a 4-0 loss) was disappointing.
"But we have dominated some games here and we should have scored two or three goals.
"Hopefully, this time we will get the rewards for all the work we have done."
Cardiff possess the least prolific attack in the division alongside Crystal Palace, with 19 goals scored in 28 games.
Moreover, the Bluebirds have failed to find the back of the net in their last four league games.
"You need goals to take points," Solksjaer said.
"We need to score goals. To get a win, you need to perform.
"You have to earn the right to win a game by doing the hard work and you have to get the quality there, especially going forward.
"Against Spurs we had so many one-on-one chances against the 'keeper, four times at least we should have been through.
"It's that little bit of extra quality that will get us some points."
Fortunately for Cardiff, Fulham have the leakiest back line in the Premier League with 62 goals given away.
The last time both sides met in the league, a Jordon Mutch goal handed Cardiff a 2-1 triumph at Craven Cottage.