The Norwegian, just over a week into his new role as Cardiff manager, is set to make his managerial debut in the Premier League, having graced the top-flight during his playing days with United.
The opponents will be West Ham, the same side he faced when making his final top-flight appearance as a player back in 2007.
A knee injury would end his playing career in the summer of that year, but the next chapter of his football life was about to begin.
He said: "My last Premier League game was against West Ham at home and we lost 1-0, Carlos Tevez scored.
"It was the following season when I got hurt and drove into the training ground and I was dreading my chat with the manager (Sir Alex Ferguson).
"He came out when I parked and he asked me how my injury was, he said, 'how are you doing son?'
"I said 'not too good, I need another operation'.
"We had a brief two-minute chat and I had a new job as a forwards coach."
Cardiff, just one place and one point above the relegation zone, face a West Ham side who are 19th in the table and reeling after shipping 11 goals in cup defeats to Nottingham Forest and Manchester City.
A win would give Cardiff some valuable breathing space, and Solskjaer felt last week's comeback win at Newcastle in the FA Cup suggests his side are ready to start moving in the right direction.
He said: "I thought the Newcastle game showed me some great signs, the way we came back from a goal down.
"We finished the game strongly compared to the other league games before, Sunderland and Arsenal, where we were hanging on for a result.
"We showed we could turn a game round we were 2-1 up, but we did not just hang on to the result we played and kept the ball and that's very important in the last 15 minutes of a game. If you are winning you get the ball and get it moving.
"As coaches we have tried to implement our ideas. It is not a be all and end all game against West Ham but it is an important game.
"If we focus on ourselves, our performance, the results will come.
"Too many people are too focused on results but when the last game of the season comes and you need those points to stay up, that's a must-win. Now it's about developing the team the way you want and getting the performance."