Manager Villas-Boas hailed his stopper's two late point-blank saves that edged Spurs to their first Barclays Premier League victory in five matches at Craven Cottage.
The White Hart Lane boss backed Lloris to capitalise on the "confidence boost" after a bout of indifferent form, including gifting Manchester United a penalty last weekend.
Wayne Rooney scored from the spot as Tottenham twice let a lead slip from their grasp for a 2-2 home draw against David Moyes' men.
Spurs sneaked to victory over Fulham on Wednesday courtesy of impressive long-range strikes from defender Vlad Chiriches and midfielder Lewis Holtby.
Ashkan Dejagah's first goal for Fulham had handed the Cottagers hope of victory in Rene Meulensteen's debut clash in sole charge.
Tottenham boss Villas-Boas admitted it was not just two thunderbolt goals that won the points, but also Lloris' gritty showing.
He said: "It was a great game for both goalkeepers.
"It's fantastic for him: he needed a game like that for his confidence.
"This can be a big confidence boost for him going forward to make decisive saves and to have this impact on the game was important for him on a personal level.
"We brought him in last year with a view to strengthening, he fought for his place and for the team: he's a top, top goalkeeper who has great ambitions for himself and for the club.
"When called into action like that he showed all his qualities."
New Fulham boss Meulensteen hailed his side's "inspired" performance, and tipped unsettled striker Dimitar Berbatov to help guide the Cottagers away from the relegation zone.
Berbatov's agent has confirmed the Bulgaria forward is "not happy" at Fulham, and will seek a move in January.
Meulensteen shrugged off talk of persuading Berbatov to stay, insisting the focus remains on the hectic December schedule.
Meulensteen said: "I thought he was fantastic.
"He was unbelievable, he led the line fantastically, and I know really, really well what Dimitar is capable of doing because I've worked with him for so long.
"The most important thing is that we have to focus now from game to game, right up until the start of January.
"I've had some good chats with Dimitar, he's a player who really cares for this club and I thought that was evident the way he performed."