Meulensteen had worked extensively with the 32-year old Fulham striker when he was at Old Trafford and hopes that chemistry will continue upon his arrival at Craven Cottage.
He added: "It is without doubt the talent Dimitar brings to the table and also it is very clear sometimes the frustration that goes with it.
"But I think that what you get with that sort of player, they are geniuses in some ways and I always find it a challenge to make sure that we can serve those players in the right way that they can bring out the best in themselves and serve the best purpose for the team."
Rene Meulensteen’s partnership with Sir Alex Ferguson was a fruitful one that saw the Red Devils win three Premier League titles and one Champions League title.
He hopes to transfer what he has learnt to the side from Craven Cottage and lift them from their current 18th place on the league table.
"I have been in England now for 12 years and worked in every department at Manchester United, and the last five years as assistant to Sir Alex Ferguson, so I know the Premier League well," he told UK press recently.
"It is obviously different being with Manchester United, we had different ambitions which were quite clear, but hopefully my experience and expertise will help Fulham climb up the table.
"It will work very similar to how I worked with Sir Alex Ferguson. Martin is obviously a very, very experienced manager in the game.
"I think it comes to a time in his life - as a manager as well - when he has got experience and he wants to step back a little bit and give the groundwork over to somebody like myself. I think we can perfectly work well together.
"People must not forget that Fulham have played a lot of strong teams already. They've played Arsenal, Liverpool, Chelsea and Manchester United so they have had a tough run.
"I think the key is now making sure that hopefully I can bring a new sort of energy to the whole place because they have got good enough footballers. Fulham is a football team, that's what they are good at.
"They just need to make sure they do the basics right, take responsibility, be disciplined and work hard and then the results will come."