The Magpies boss is under no illusions about the size of the task awaiting his side at St James' Park tonight, especially having lost 4-0 to the same opponents on the opening day of the Barclays Premier League season, and accepts that on paper City are a stronger group than Newcastle.
But Pardew also feels that the competition may not feature as highly in Manuel Pellegrini's priorities as it does in his and hopes to take advantage of that.
"If your desire to win something is stronger than the opposition, then it does give you a slight benefit. We'll be leaning on that for sure." said Pardew.
"But if we could beat Manchester City I think it would get people talking because then we'd be down to the last eight and it all becomes a bit serious then.
"I think any team in the Premier League can consider this a tournament they can win. For the Champions League clubs maybe it's a little down on their agenda but it's high on our agenda.
"For us this year it is a priority. We want to win a trophy for our fans.
"It's tough to beat them....they have a squad of 24 international players so we're coming up against 11 internationals even if it is a slightly weakened City team.
"When they turn on their turbo chargers, with the players they've got, they're almost impossible to deal with.
"But they're vulnerable as well and particularly away from home results haven't been as good as they would like.
"That is some comfort for us, that we could catch them on an off night."
Pardew plans to field a strong team on the night, but accepts changes are a necessity after a draining defeat in the Tyne-Wear derby on Sunday.
"We're in a run of three games in six days and we've got to make sure we're at full tilt for the Premier League games," he said.
"I've got three or four players I feel need to come in and play who have a chance of playing against Chelsea.
"It's an opportunity for players really close to the first team to make a stand for Chelsea. That question is in front of me: what team do I play versus Chelsea? I want a few people to give me a problem."
Pardew has confirmed Cheick Tiote will start as captain, just two days after being given a seven-month suspended prison sentence for possession of a fake driving licence.
Reflecting on the case, the manager said: "There are times when international players come abroad and don't actually understand the rules. I think it was a misunderstanding."