Bruce, who already has James Chester, Allan McGregor and Robert Koren in the treatment room ahead of Sunday's visit to Tottenham, will also be without forwards Sone Aluko and Danny Graham - each of whom were on the receiving end of poor challenges by Barry last Saturday.
Barry was not penalised for the tackle which has left Graham out for three weeks and appeared fortunate to get away with a caution for a studs-up lunge on Aluko later in the game.
Bruce, who cannot call on Jake Livermore against his parent club and may also be without Robbie Brady (hernia), was strongly critical of both Barry and referee Neil Swarbrick's contributions at Goodison Park.
"I know how difficult it is for referees and linesmen and the last thing I want to do is complain about the referees...but the big decisions went against us last week. They were two horrible tackles," he said.
"There should have been a red card. End of story. The challenge on Aluko was reckless, dangerous and could have really injured him.
"In that respect we expect referees to do their jobs, especially in the Premier League.
"These lads are professional now, so to miss something like that concerns me. We could all miss an offside, it happens, but a tackle like that when you're 12 yards away? I was 30 yards away and I was incensed.
"Graham could have been out for three of four months, not weeks, so we have to stamp that out. But the tackle on Aluko, that's the one that really does break people's legs and does them damage for more than a couple of weeks.
"I can't see Graham being available for a few weeks and I don't think Aluko will play. His was a challenge he hasn't really recovered from, but thankfully he's not too badly injured."
Bruce, who knows all about the perks of being with a top side from his years as a player with Manchester United, also suggested that Hull may not be getting decisions that the title challengers would expect.
He did, though, fall short of accusing officials of anything untoward in that regard.
"Let me tell you, if it had been a Manchester United player or a Manchester City player (being tackled) there would have been a different reaction to the one we got," he continued.
"We accept that, we're a small club in the Premier League punching above our weight.
"Is there a bias? I just think the big clubs have bigger support, make bigger noise, challenge the referee for everything.
"Let's just hope from now we get a fair crack of the whip."
Bruce's frustrations are understandable given the way his resources have been stretched this week.
The likes of Steve Harper, Stephen Quinn, David Meyler, George Boyd and Yannick Sagbo are all on hand to return to the starting XI in place of the many absentees, but Hull's bench is likely to be a combination of peripheral squad players and others who are short of full fitness.
Throw in a Capital One Cup fourth round clash against Spurs on Tuesday, also at White Hart Lane, and Bruce's task of keeping his senior men in prime condition looks even harder.
"We couldn't have wished for a more difficult place (to go with injuries). We have arguably got six or seven missing which is too much for us," said Bruce.
"We've got a difficult couple of days coming up, to go there twice, because they are a top side."