The Uruguay international sat out the last of his 10-match ban for biting Chelsea's Branislav Ivanovic during Saturday's 1-0 home defeat to Southampton.
He is likely to go straight back into the team for the Capital One Cup tie at Old Trafford despite playing just a handful of competitive games at international level since April.
Suarez also failed in his attempts to manufacture a move away in the summer but Toure expects to see a fully fired-up striker on his return.
"Wednesday is going to be massive for us. He (Suarez) is a winner and he wants to win, working hard, fighting," said the defender.
"He is really difficult to attack in training. You saw in the first international he played in he scored twice and that shows how strong this guy is.
"Suarez is a fantastic player and a top striker who can score a goal from any side.
"But Daniel Sturridge has been playing very well this season so we will have two very strong strikers."
Having played for Manchester City, Arsenal and now Liverpool, Toure would probably run Suarez a close second as the most unpopular player in United fans' eyes.
But he is far too experienced to be daunted by such a prospect and is concerned more with Liverpool correcting the errors which led to their first defeat in 13 league games.
"When I was young I dreamed of those games (at Old Trafford). I will try to do everything to try to win this game," he added.
"We need to have the courage to pass the ball. For the four previous games we've been passing the ball and everyone was working hard but we failed as a team (against Southampton).
"The group haven't done the job. It is going to be a very important game for us."