Chelsea vs Fulham
Chelsea have midfielder Ramires available following his European suspension as they bid to end a four-match winless run. Manager Jose Mourinho is expected to make changes after the defeat to Basle, with Fernando Torres in line for a recall up front.
Fulham striker Dimitar Berbatov (hamstring) will have a late fitness test. His fellow forward Darren Bent is back in the squad after a hamstring problem, but Bryan Ruiz (ankle) will miss out. Defenders Aaron Hughes (thigh) and Matthew Briggs (hernia) are still sidelined along with first-choice goalkeeper Maarten Stekelenburg (shoulder).
Liverpool vs Southampton
Liverpool defender Daniel Agger is expected to return after missing Monday's draw at Swansea with a side strain. Playmaker Philippe Coutinho is out for several weeks after undergoing a shoulder operation so the likes of Iago Aspas and Raheem Sterling will be pushing for a recall. Luis Suarez sits out the game, the last leg of his 10-match suspension that began last season.
Southampton left-back Luke Shaw has been passed fit despite limping off in last weekend's draw with West Ham. Fellow left-back Danny Fox remains a doubt with an ankle complaint and Japanese forwardTadanari Lee may also miss out.
Newcastle vs Hull
Newcastle will be without central defender Steven Taylor who has damaged a hamstring in training and could miss the next three games. Striker Shola Ameobi is also out with a knock picked up on international duty with Nigeria, while midfielder Jonas Gutierrez continues to work his way back from a hamstring problem.
Hull will be forced into changes. Captain Robert Koren has broken a bone in his right foot and faces up to eight weeks out and left-back Maynor Figueroa has been granted compassionate leave due to a family problem. Stephen Quinn and George Boyd are eyeing Koren's spot in midfield, Liam Rosenior is expected to replace Figueroa in the absence of Paul McShane (hamstring), and striker Yannick Sagbo is back from suspension.
Norwich vs Aston Villa
Norwich have no fresh injury concerns. Striker Gary Hooper was an unused substitute at Tottenham last weekend and could make his competitive debut following a pre-season shin problem. Elliott Bennett is the only definite absentee as the winger recovers from surgery on a cruciate ligament injury.
Aston Villa manager Paul Lambert is likely to call on Ciaran Clark to fill the defensive void created by Jores Okore's cruciate ligament injury. The 21-year-old was ruled out for nine months after being injured in last week's defeat by Newcastle, and Nathan Baker is another contender to step in. Charles N'Zogbia is unavailable due to a long-term Achilles injury.
West Brom vs Sunderland
West Brom forward Stephane Sessegnon could make his debut against his former club after receiving a work permit. Strikers Shane Long (knee) and Matej Vydra (hamstring) are doubtful for the match while Steven Reid, Zoltan Gera and George Thorne are still working their way back to fitness. Goalkeeper Ben Foster is recovering from surgery on his foot.
Central defender John O'Shea returns to the Sunderland squad after missing last weekend's home defeat to Arsenal due to suspension. The squad could also feature midfielder Lee Cattermole following his recovery from an ankle problem. Italian Emanuele Giaccherini has shaken off the tight hamstring which forced him to miss the Arsenal game, but defender Wes Brown is absent due to a calf problem.
West Ham vs Everton
West Ham manager Sam Allardyce remains short of attacking options. Andy Carroll (heel) is being sorely missed, and new signing Mladen Petric is not match fit. Attacking midfielder Joe Cole (hamstring) and Stewart Downing (leg) are also absent, as is defender George McCartney who has returned to training following a knee injury, while Alou Diarra (knee) is a long-term casualty.
Loan signing Romelu Lukaku is set for his Everton debut. Fellow striker Arouna Kone is also expected to return to the squad after a knee injury along with midfielder Darron Gibson, who has not featured this season because of a knee injury. Midfielder Steven Pienaar (hamstring) is rated 50-50 but centre-back Antolin Alcaraz is still recovering from a similar problem.
Arsenal vs Stoke
Midfielder Mikel Arteta could make his first appearance of the season after recovering from a thigh injury. Santi Cazorla (ankle) remains sidelined, so record signing Mesut Ozil is set for his home debut. Czech playmaker Tomas Rosicky (thigh) is unavailable, along with France Under-21 forward Yaya Sanogo (back), German forward Lukas Podolski (hamstring) and longer-term absentees Alex Oxlade-Chamberlain and Abou Diaby (both knee).
Midfielder Charlie Adam has been Stoke's only injury concern but manager Mark Hughes expects the Scot to be fit. Adam needed stitches in a cut after a training ground incident. Midfielder Stephen Ireland and forward Mark Arnautovic, who made their debuts off the bench against Manchester City last week, are pushing for first starts.
Cardiff vs Tottenham
David Marshall is set to return to the Cardiff starting line-up after overcoming a hip problem, while Craig Bellamy is also back in the squad. Striker Andreas Cornelius remains on the sidelines with the ankle injury he suffered at Accrington in the Capital One Cup.
Tottenham left-back Danny Rose is a big doubt after he limped off in Thursday night's Europa League clash against Tromso with an ankle injury. Defender Younes Kaboul (adductor) and midfielder Mousa Dembele (ankle) could be fit for action despite also being replaced against the Norwegians. Etienne Capoue (ankle) and Aaron Lennon (foot) are out, winger Nacer Chadli (adductor) is doubtful, but defender Vlad Chiriches could make his debut after receiving a work permit.
Crystal Palace vs Swansea
Crystal Palace will be without the suspended Kagisho Dikgacoi, sent off at Manchester United last weekend. Winger Jerome Thomas is back in training following an ankle injury, with Yannick Bolasie also nearing a return from his hamstring problem. Jonny Williams and Jack Hunt (both ankle) and Joel Ward (calf) will miss out with captain Paddy McCarthy (groin) and striker Glenn Murray (knee) also absent.
Swansea captain Ashley Williams is doubtful due to an ankle injury. The defender missed the win in Valencia on Thursday. Winger Pablo Hernandez will definitely miss out with his hamstring strain, while left-back Neil Taylor is edging closer to a return from his thigh problem.
Manchester City vs Manchester United
Manchester City midfielder David Silva could return after missing two games with a thigh injury. Right-back Micah Richards (hamstring) is back in training after missing the start of the season and could be in contention but left-back Gael Clichy is not yet ready to feature. Captain Vincent Kompany came through his comeback match against Plzen unscathed but fellow centre-back Martin Demichelis (knee) is a long-term casualty.
Manchester United manager David Moyes looks set to plunge Nemanja Vidic and Rio Ferdinand into their third match in a week. The pair have not operated in tandem three times in such quick succession since 2010 but Moyes seems certain to stick with them following the victories over Crystal Palace and Bayer Leverkusen. Rafael (hamstring), Danny Welbeck (knee) and Phil Jones (ankle) missed the midweek Champions League win, while Nani is available after suspension.