The Cottagers have endured a topsy-turvy start to the season, with last weekend's heavy home defeat to Arsenal followed by a stern Capital One Cup test against fourth tier Burton.
Before that, though, Martin Jol's side kicked off the campaign with a hard-fought and somewhat surprising 1-0 win at Sunderland.
It was a victory borne out of resilient defending and former Newcastle defender Hughes believes that will be key again at St James' Park.
"We went up there a couple of weeks ago to play Sunderland and got a good result," the defender told the club's official website, www.fulhamfc.com.
"This weekend will be very much similar to that game as they'll have a big crowd behind them, the team will be looking to get off to a good start and we're going to have to do something similar to what we did at Sunderland.
"We'll have to be as strong in defence as we were at Sunderland, but maybe try and use the ball a little bit better.
"We all know Sunderland wasn't our best performance football-wise, but in terms of being solid and defensively strong and everyone working really, really hard it was as good as we've had in a long time, so we need another performance like that.
"With their crowd, if they get off to a good start then they'll get right behind them and it could make for a very difficult game.
"But if we can get off to a good start ourselves and try and quieten them a little bit, then it will maybe make the day a little bit easier.
"If we could snatch an early goal then it would give us something to hold on to.
"It means then that they have to come out looking for a goal and push forward a little bit, certainly as the game goes on, and they'd maybe leave a few spaces that we could exploit."
It is a big match for Newcastle, for whom things have not been easy of late.
Peculiar goings-on behind the scenes and a lack of transfer activity over the summer has all been compounded by a poor start to the campaign.
"At a club like Newcastle there's always something to talk about," Hughes, who made more than 200 appearances for the Magpies, said.
"It's very much that when things are going well, the expectation's really heightened, almost to the point where it's over the top, and then if things aren't going well it's all doom and gloom and it's the end of the world.
"It just comes with being at Newcastle because it always has been very fanatical. I think as a player you always try and stay somewhere in the middle; you just get your head down and work hard, and look to get through it.
"And equally, when things are going well, you don't get carried away because you know that round the corner anything can happen.
"I think that's what they'll be doing up there, they'll just be keeping their heads down and working hard. We can expect a tough game on Saturday, we know what's going to happen, we know they're going to come out and really push hard to get off to a good start.
"From the outside sometimes things can seem all over the place but I'm sure the players up there will be ready to go on Saturday and we'll make sure that we are too because we're expecting a tough game."