David Moyes' first league game in charge of Manchester United will be at the Liberty Stadium in Saturday's tea-time kick-off.
With Swansea having produced two encouraging performances in their Europa League tie against Malmo, and having spent well during the transfer window, many are predicting a difficult start for Moyes as he takes on the unenviable task of succeeding Sir Alex Ferguson.
The former Everton boss said it was "hard to believe" United's opening five games also include fixtures against Chelsea, Liverpool and Manchester City.
But Laudrup has pointed out that no side welcomes the task of facing United, regardless of the time of the season.
He said: "I have to be careful when people say this is a good time for us to play United. We could lose 3-0 on Saturday.
"There is never a right time to play a team like United because of the quality they have.
"But we have to play them at some stage and I suppose at the beginning of the season it is not too bad.
"I look at their XI and who could play and whatever they do they have a really strong squad.
"Anything is possible when you play them. But we have to play all the big teams and it is not too bad to play them now than in October.
"But it is still difficult, so don't laugh at me if they beat us on Saturday."
United's pre-season preparations have not been helped by the uncertainty over Wayne Rooney's future, with Chelsea having had two offers rejected for the wantaway striker.
Moyes is to assess Rooney's fitness, following his outing for England against Scotland, before deciding whether to include him in his squad for the trip to south Wales.
But Laudrup is preparing to face a side including the 27-year-old.
The Dane said: "Rooney played last night [Wednesday] so I have to take that into consideration.
"He seemed quite fit to me. I don't know if his situation affects other players in the squad. I don't think it has a huge influence, maybe more from the outside."
Laudrup will be without midfielder Jonathan de Guzman for the opening Premier League fixture after the Dutchman suffered concussion while away on international duty.
But Pablo Hernandez is set to feature after getting over a groin strain.
Record signing Wilfried Bony is also set to make his league debut although he will only return to south Wales from Ivory Coast's friendly defeat to Mexico in New Jersey on Thursday.