Tuchel has set his side the target of winning more than they lose this season, and with 10 wins to 11 defeats so far, that is the record they must work on between now and the end of the campaign.
"We are now just going to look at the results in our remaining four games," he said
"Before the season started, we set ourselves the aim of wanting to win more games than we lose.
"We now have four games to turn that record around. I expect my team to be fully focused on the game, on the result and playing attacking football."
Tuchel is still without the injured Jan Kirchhoff, who moves to Bayern Munich in the summer, Heinz Muller and Eric Maxim Choupo-Moting.
The stakes are arguably higher for Frankfurt, who boosted their European qualification hopes with a 1-0 win over Schalke last weekend.
After losing 3-1 at home to Mainz in the reverse fixture, Armin Veh expects a tough challenge for his side away from home.
"It's nice that we don't have far to travel, but this certainly isn't going to be a soft derby," he said.
"The stakes are still high for both sides."
Veh hopes to have top-scorer Alexander Meier back in action after he missed the Schalke game last week while Sebastian Rode will begin.
"I am not 100 per cent certain about my starting XI until I know whether Meier can play," he added.