Lampard became England highest scoring midfielder with his 28th goal for his country in last night's 8-0 demolition of San Marino in a World Cup qualifier.
Defoe knows all about Lampard's qualities stretching back to their days as team-mates at West Ham more than a decade ago, and feels he would be irreplacable should Chelsea let him leave this summer.
The Tottenham striker, who netted twice against San Marino, said: "I was with Frank at West Ham when I was really young and, even then, his finishing was unbelievable
"He finishes like a forward. There are not many like him, he loves scoring goals and when, he gets the chances, he doesn't miss.
"I don't know his situation at Chelsea but in my opinion he is someone you can't replace because of the amount of goals he has scored over the years.
"He is a special player. He can easily go on for another two or three years.
"At the end of the day you know you are going to get goals. You know what you are going to get from Frank and goals win games.
"I'm sure Chelsea won't get rid of him. He is a special player."
Lampard already has an eye on the more testing challenge England will face against current group leaders Montenegro in Podgorica on Tuesday evening.
They maintained their two point advantage over England courtesy of a 1-0 away win over Moldova last night.
Lampard said: "Some of their players are playing at the top level in European football right now and we have been there before so we know the dangers.
"You look at the state of the group and it's a really critical game and we have to be ready for it."
Defoe believes England are capable of repeating the level of performance shown against San Marino.
He said: "We passed the ball well and created a lot of chances. They gave us an own goal early on and then we created and took the chances.
"We were delighted with the performance. At some stage you are going to get the goals. It is important to try and get a good performance and we managed to do that.
"Even if you take away the goals, the way we moved the ball was good, the movement was good, and everyone is happy.
"It is good for confidence because sometimes you might play a game like this and it might be a horrible game where you don't play well but still win.
"It is important to have had a good result and a good performance and all the things we worked on in training, we did well and the manager is happy."
Defoe added: "The lads are more than experienced to go into a second game and do the same.
"It will be a different game but, with the players we've got, and the way we are playing at the minute, we can do the same."