By FOX Sports Staff
It leaves the Serie A outfit with little hope of progressing to the quarter-final of the Europa League.
The Italians were undone by Spurs star Gareth Bale once again - more than two years on since he destroyed former Inter right-back Maicon in the UEFA Champions League to announce himself on the world stage - as he put the home side in front after just five mintues.
Bale then turned provider for Jan Vertonghen after Gylfi Sigurdsson had scored the second goal for Tottenham to complete the rout.
"Obviously I believe that they played better than us and deserved what they got," Stramaccioni said.
"First of all we suffered from a physical point of view, they created us lots of problems with their aerial game but having said that, even if we had a negative night we had two great chances to score and we have not been able to do it."
Rodrigo Palacio's miss was the most telling as he failed to beat Brad Friedel in a one-v-one situation after sneaking through on goal.
"We all know that it is going to be very hard, a tough situation to face but at the end of the day we are Inter," Stramaccioni said.
"We want to win the second leg and, as we all know, football is a beautiful game and you never know what will happen but we are fully aware it is going to be very hard."
Inter must now turn their attention to Serie A where they host Bologna at the weekend.