Pre-match: Sir Alex Ferguson drops a bombshell by leaving Wayne Rooney out of the starting XI. The Scot also selects Ryan Giggs for his 1,000th senior appearance.
Four minutes: Cristiano Ronaldo gets a first chance to try his luck with a free-kick at his former home ground but his effort canons off the wall.
11: Gonzalo Higuain misses the target with the best chance so far after neat interplay between Angel Di Maria and Mesut Ozil.
14: Giggs hits a superb cross for Robin van Persie at the far post but he mis-hits and Sergio Ramos bundles clear.
20: Nemanja Vidic meets a corner and sees his powerful header come back off the post. The loose ball rebounds off Danny Welbeck but straight at Diego Lopez on the line.
33: Goal disallowed for Real. Higuain stabs home from a corner but only after Ramos is penalised for a challenge on Van Persie.
34: Van Persie's shot is shakily parried by Lopez, who then does well to stop Welbeck's follow-up.
43: Di Maria departs with an injury, with Brazilian playmaker Kaka on in his stead.
48: Manchester United take a 1-0 lead. Nani revives an attack featuring Rafael and Van Persie before Ramos turns the ball over his own line after a slight touch from Welbeck.
57: Referee Cuneyt Cakir stuns Old Trafford with what seems a harsh red card for Nani for high feet as the winger challenges Alvaro Arbeloa.
61: Rafael's arm saves United on the line as Higuain puts his effort straight at the defender.
66: Luka Modric - on straight after the red card - fires in a fearsome equaliser from 25 yards.
69: Madrid go 2-1 up as that man Ronaldo slides in at the far post to convert Higuain's cross.
73: Rooney makes his belated entrance as a replacement for Tom Cleverley.
80: A chance materialises for Welbeck, who blasts against Ramos leading to muted appeals for handball.
83: Michael Carrick sees his point-blank header beaten away by Lopez.
84: Van Persie is denied by the advancing Lopez as United surge and Rooney hooks a good chance over the crossbar.
89: Kaka hits the near post as the visitors take advantage of United's increasing desperation.
92: Lopez reacts smartly to save a Vidic header from eight yards.
94: Jose Mourinho shakes Ferguson's hand before the final whistle and walks away without celebration.