Benitez was jeered during Sunday's 0-0 draw with champions Manchester City at Stamford Bridge, his first game in charge following the sacking of the popular Roberto Di Matteo.
But goalkeeper Petr Cech has warned his team-mates to accept owner Roman Abramovich's hiring and firing policy.
"You adapt or you're out. It's as simple as that," Cech said. "You're here to play, you're here to do what the club and manager wants you to do. If you don't like it, you can leave."
Elsewhere on Wednesday, Everton face Arsenal at Goodison Park, Southampton look to build on their home win over Newcastle against Norwich at St Mary's and Newcastle try to bounce back from their third league defeat in succession at Stoke.
Swansea, who drew 0-0 with Liverpool on Sunday, are at home to high-flying West Brom, while Liverpool travel to Tottenham.
League leaders Manchester United welcome West Ham to Old Trafford while local rivals Manchester City - currently one point behind - aim to keep pace with Sir Alex Ferguson's side as they make the short trip to Wigan.
On Tuesday, Harry Redknapp's first match in charge of QPR ended in a goalless draw at Sunderland in the Premier League.
The new boss had substitute keeper Rob Green to thank for gaining a point as his spectacular save denied Steven Fletcher.
The result extended the basement boys' winless start to the season to 14 games, but they at least ended a run of three straight defeats.
Redknapp's men moved four points behind second-bottom Reading, who went down 1-0 away to fellow strugglers Aston Villa.
Christian Benteke's header 10 minutes from time settled a dull match and moved Villa out of the bottom three.
Tuesday's Premier League Results
Wednesday's Premier League Fixtures
Chelsea vs Fulham
Swansea vs West Brom
Everton vs Arsenal
Southampton vs Norwich
Stoke vs Newcastle
Tottenham vs Liverpool
Wigan vs Man City
Man United vs West Ham