The Magpies have struggled to cope with domestic and European exertions this season, which was epitomised by Sunday's 2-0 defeat at Southampton.
The result leaves them 14th in the table and just four points off the drop zone heading into this week's trip to the Britannia Stadium.
While manager Pardew can call upon captain Fabricio Coloccini after suspension, he will be without Hatem Ben Arfa, Yohan Cabaye and Shola Ameobi once again.
"We're worried, of course we're worried, because we are Newcastle United and we've really got that dressing room to take into Wednesday night," he said.
"It's not like we can add four or five players from the squad into that group.
"That is our group and they have been soundly beaten and are going to another tough place.
"We have three days to try and lift the team to try and get ready for another tough game."
It is a game that Pardew hopes the Newcastle fans turn up in force for after more than 2,000 came down to St Mary's.
"I am looking forward to the next game and hopefully performing better for our fans," Pardew said. "They came a long, long way and they are the greatest set of fans in the country, in my opinion.
"Perhaps we need them more than we did last year because the team really needs a lift."