Atleti will be fully expected to do just that when they host Group B whipping boys Hapoel Tel-Aviv at the Vicente Calderon on Thursday.
Simeone takes some caution into the match, however, after he saw a much-changed side relinquish their 16-game unbeaten run in Europe at Academica last time out.
The Argentinian coach, who was unaware of his personal milestone before Wednesday, has called on his side to go full throttle for victory and assure their place in the next round.
"The match tomorrow [Thursday] has to be approached with concentration," he told a press conference.
"We need to play well and stay in a position to try and qualify first and then whatever happens beyond that.
"If we can win this match then we will be able to return to this competition in February when it is an important time in the Europa League.
Asked about his milestone, he added: "I was not aware, I read it this morning. As a coach you live for the moment. You have to focus on things, there will be time later to look at the statistics."
Simeone is unlikely to replicate the nine changes he made last time out against Academica, but first-choice goalkeeper Thibaut Courtois is to be rested for Sergio Asenjo.
"I am trusted in Europe. I'm playing well and I'm happy," Asenjo said.
"Last year was a transitional one for me, but playing in Europe is important and getting minutes is great."
Sought-after striker Radamel Falcao, who has not netted in his past three games, is yet to play in the competition this season and is not expected to be risked.