By ESPNSTAR.com staff
The two clubs meet in Turin in Group E with Juve knowing that a defeat to the current European champions would see them exit the competition at the group stage.
A win for the Blues would see them progress to the knock-out round as they are level on points with Group E leader Shakhtar Donetsk on seven points while Juve sit a point adrift with two games left.
"We've ended up in one of the toughest groups of this year's Champions League and will be facing the defending European champions," Marchisio said.
"They've invested a great deal in the summer and bolstered their squad.
"It's impossible to single out a player to fear though, the group is their strength and this is precisely what led them to win last season's trophy.
"We've got great respect for Chelsea, but we'll do all we can to go through."
The first game between Juventus and Chelsea in matchday 1 saw four goals shared between the two teams as the Italian visitors fought back from two goals down.
Now both teams need points to underpin their Group E ambitions and Marchisio believes the big stakes on the line in Tuesday's game means tiredness won't be an issue in the game.
"Such big games help you find added energy and anyone would want to be involved in them," he said.
UEFA notes that Chelsea have won only once in eight visits to Italy which was a 4-0 group stage success at Lazio in 2003/04.