Six players have pulled out of Low's squad and, although the Germany coach has added three new names, he is nonetheless down to only 19 fit players for the clash in Amsterdam.
Mesut Ozil and Miroslav Klose were the latest to withdraw due to injury and illness respectively, following on from Bastian Schweinsteiger (flu), Marcel Schmelzer (foot injury), Jerome Boateng (torn groin muscle) and Toni Kroos (stomach bug).
Inevitably the question is whether any of the players would have pulled out had it been an important qualifying match and not just a friendly, but Germany general manager Oliver Bierhoff said he trusts all of the ailments are genuine.
"What annoys us is not having the players here, but we have enough trust in the clubs and the players themselves," he said.
"It is always a consideration for clubs and the players, at certain times of the year like now, how much of a risk should be taken and it is not optimal for us to have these injuries, but that does not mean we should question the point of these games."
Bayern Munich midfielder Thomas Muller has made the trip to Amsterdam, despite having a cold, meaning Low only has 18 fit players, including Sebastian Jung, Sven Bender and Lewis Holtby, who were all called up today.
Eintracht Frankfurt defender Jung is therefore in line for his Germany debut while Holtby could pick up his third cap, and they are certainly happy to be involved, according to Bierhoff.
"I think it is important that we have such tests for the team and lots of players are delighted to be here," he said.
"Games for the national team are always special. I was lucky enough to make 70 appearances and it was always an honour."
It is also an honour for goalkeeper Rene Adler, who is set to return after a two-year absence, mainly due to a serious knee injury which put his entire career at risk.
"I am delighted to be here. It is great recognition and it makes me proud to be back here," he said.
"It is not easy when you see where I was six months ago when it seemed I was closer to ending my career.
"All I dreamt about was merely to play in the Bundesliga again. Of course I did not dream of the national team when I was in the doctor's clinic all the time, but I am trying to enjoy it, but also to play well and ensure something positive comes out of this game."