Even Wilshere has expressed surprise at being catapulted back into the Three Lions fold for next week's friendly with Sweden in Stockholm just three games into his comeback after spending 17 months on the sidelines.
Although Wenger has spoken to Roy Hodgson and reached a compromise with the England manager about how long he would be involved for, he has also expressed a preference for Wilshere not to be picked at all.
After so long out of the game, it is a stance Ferguson completely agrees with.
"I can understand where Arsene is coming from with that (Wilshere complaint)," he said.
"When you are out for a long period and play your first game, the adrenaline helps you.
"But there is a physical reaction a few days later, which is what we are worried about with Chris Smalling.
"You never know after someone has been out for so long."
If anything, Wilshere's value to Arsenal is greater than that of Smalling - who may need to replace Jonny Evans at Aston Villa on Saturday.
Little wonder Wenger is so troubled, something Wilshere has acknowledged in an interview with BBC's Football Focus.
"Maybe it is a bit too soon (to be called up) because I have only played three games since I have been back," said the midfielder.
"But it is great for my head and my confidence to know I am in the new manager's plans.
"The last time I played for England was under Fabio Capello and now there is a new manager and staff, so I did not know the thinking of the new tactics - would I fit in? Am I in their plans?
"To know now the manager has picked me and he is looking at me for the team is good for me.
"It is a new chapter for me in my football career, the last time I played for England was 17 months ago. Now everyone can see there is a different style of play.
"For my confidence it is nice to be picked and know I am in the new manager's plans.
"There are a lot of young players in there now, which is great for me.
"I played with the likes of Tom Cleverley and Chris Smalling in the under-21s and to see them breaking into the first team now is good for the future."
Like Wilshere, Smalling has yet to appear for Hodgson, his old boss at Fulham.
He has been overlooked this time, but Cleverley will be there, along with club colleagues Danny Welbeck, Ashley Young and Wayne Rooney for a fixture which, from Ferguson's perspective, is utterly pointless.
"There's always concerns with England but there's no point going on about it all the time," he said.
"Friendly games at this time of year don't mean a thing to me. It won't be a full squad anyway because players will drop out.
"I've no issue with the younger players playing (for England) - Cleverley, Welbeck and Young - no problem. Nor Rooney.
"I don't know if all of them will play but they're available."
Meanwhile, Ferguson has confirmed Manchester United skipper Nemanja Vidic is on track to recover from his latest knee operation by Christmas.
The 31-year-old made his comeback from cruciate surgery at the start of the season but within a month was experiencing more discomfort, which condemned Vidic to yet another stint on the sidelines.
United have not exactly been watertight in the Serbian's absence, even if they have climbed to the Premier League summit and booked their place in the Champions League knock-out stages.
However, clearly, the return of one of the world's best defenders would have a positive impact on United's season.
And Ferguson expects to be welcoming his captain back during the packed festive programme.
"I think it's Christmas time for Vidic," said Ferguson.
"If we get him back for Christmas, then I'll be happy.
"There's been no setback but we cannot take any chances after his cruciate."