Nacho Scocco gave Newell's an 11th minute lead - and the home side's hopes were further hit four minutes before half-time when defender Jorge Curbelo was dismissed.
However, Mauro Obolo's 80th minute goal denied the Rosario side victory with an equalising goal 10 minutes from time.
Colon Santa Fe launched a stunning late comeback to earn a 2-2 draw at Quilmes, who were in control with first half goals from Juan Cobo and Ernesto Goni.
However, Goni gave the visitors hope with an own goal a minute from time - and the visitors made Quilmes pay a minute later with Emanuel Gigliotti's equaliser.
The mid-table clash between All Boys and River Plate finished goalless, with River Plate midfielder Leonardo Ponzio sent off at the end.