Tim Wiese has already confirmed he will be moving to Hoffenheim while the northern Germany club has announced that a further trio will be released.
Markus Rosenberg, Mikael Silvestre and Lennart Thy are also going to make their final appearances in a Bremen shirt this weekend.
"It was not an easy decision because Markus has been a reliable player for us and has always done a good job," said Bremen's director of sport Klaus Allofs.
"But at the end of the day, he scored too few goals and we have decided to do something new in our attack.
"Mikael joined us two years ago and has always behaved correctly.
"He has helped us with his experience, but it was not really a huge success story.
"We wanted to keep Lennart, but only on the condition that we would loan him out, but he has opted for a different way which we have got to accept."
They leave behind a team which is unlikely to be playing in Europe next season after losing their last three games, although there is still a faint glimmer of hope that they can sneak into the top seven.
However, to do that they need to beat third-placed Schalke and also hope results involving Hannover, Wolfsburg and Nurnberg go their way.
"All we are thinking about is playing a successful game in front of a full house and putting on a decent performance," said Bremen coach Thomas Schaaf.
"If we achieve that, then and only then will we take a look at the league table to see where it has got us."
Schalke are already sure of their place in the Champions League next season by virtue of finishing third and they too say goodbye to a player tomorrow with Spanish veteran Raul playing his last game for the club after being given an emotional send-off last weekend.
His strike partner Klaas Jan Huntelaar still has a something to play for, though, as he bids to clinch the league's top goalscorer award.
The Dutchman has netted 27, one goal more than Bayern Munich's Mario Gomez.
"It would be fantastic to achieve that," he said. "That is what I am concentrating on now that the team has already reached its goal for the season."