Reina is in the frame to start Saturday's clash and could come up against England internationals Stewart Downing and Glen Johnson.
"For those of us who play our club football in England this is a very special game," Reina was quoted by the club's website as saying.
"I'm looking forward to it and I hope to play in it but [Spain boss Vincente] Del Bosque must decide that.
"There is no such thing as a friendly these days. Whenever you go away with your national team you always want to win.
"We are champions of Europe and champions of the world, and we want to keep winning."
Reina is competing with Iker Casillas and Victor Valdes for Spain's No.1 jersey.
"When we go away with the national team there are 23 players who are very important players with their clubs but only 11 can start," he said.
"You have to accept your role and I always feel very lucky to be there. It's an absolute pleasure to be part of the squad.
"To be part of what's been achieved over the last few years is a dream for any footballer."
Reina's dad, Miguel, played for Barcelona and Atletico Madrid in the 1960s and 1970s.