Cacau fired home four minutes into injury time as Germany somehow salvaged a draw in a dramatic finish to their friendly international against Euro 2012 co-hosts Poland in Gdansk.
Having reeled off a perfect record of eight wins to become the first side to qualify for the finals, the Germans were given a much sterner test by the Poles and looked like sliding to defeat.
Jakub Blaszczykowski fired home a penalty in the final minute after a foul by German goalkeeper Tim Wiese on Pawel Brozek to put the Poles 2-1 up.
But there was still time for Cacau to slam an equaliser into the roof of the net after Thomas Muller found the Brazil-born striker on the left side of the six-yard box.
Michal Kadlec had a brace inside 12 minutes before Jan Rezek and Daniel Kolar struck in the first six minutes of the second half to complete a 4-0 win for the Czech Republic against Ukraine.
Kadlec, whose late penalty salvaged a point for the Czechs in Scotland on Friday night, lashed home another spot-kick after Vyacheslav Shevchuk brought down Rezek, and then headed home Jaroslav Plasil's corner to make it 2-0.
Rezek scored number three two minutes into the second half before Vaclav Pilar crossed for Kolar to get the fourth.
The defeat comes on the back of losses to France, Sweden and Uruguay for Ukraine.
Jurgen Klinsmann's first away match in charge of the United States ended in defeat as they lost 1-0 to Belgium in Brussels.
Nicolas Lombaerts got the only goal in the 55th minute.
Real Madrid duo Gonzalo Higuain and Angel Di Maria were amongst the goals as Argentina defeated Nigeria 3-1 in a friendly in Bangladesh.
Higuain and Di Maria both netted in quick succession to put Argentina 2-0 up after 26 minutes and in control of the contest.
Nigeria pulled a goal back right after half-time through Chinedu Obasi, but Argentina sealed the victory when Uwa Elderson inadvertently deflected the ball into his own net midway through the second period.
Ecuador saw off Costa Rica 4-0.
Christian Suárez opened the scoring in the 20th minute, with Jaime Ayovi doubling the advantage six minutes later.
Segundo Castillo made it 3-0 just after the hour mark and Christian Benitez rounded off the success 12 minutes from time - five minutes after Costa Rica had David Guzman dismissed for deliberate handball.
Second half goals from Teofilo Gutiérrez and Jackson Martinez gave Colombia a 2-0 win in Jamaica.
Oscar Cardoza netted twice in the last four minutes to put the gloss on Paraguay's 3-0 win in Honduras, after Nestor Camacho had opened the scoring in the 31st minute.
Two first-half penalties from Giancarlo Maldonado proved decisive as Venezuela earned a 2-1 win over Guinea, who replied through a spot-kick of their own - from Ibrahima Camara - 11 minutes from time.