Four decades have passed since Augsburg last beat their Bavarian rivals at home and Weinzierl feels that the time has come to change that statistic.
"The derby against Nurnberg is a big challenge and we desperately want to win it," Weinzierl said.
"We're really looking forward to this game. We haven't beaten them at home in 40 years and we want to change that.
"Losing 2-1 to them last season hurt us."
Victory would not only break that taboo, but it would take Augsburg into uncharted waters.
In their previous two seasons in the top flight, they never picked up more than 33 points.
"With a win on Sunday, we would already have more points after 21 matches than we did after the entire last season, but it's going to be hard work and we have a lot of respect for Nurnberg," Weinzierl added.
Nurnberg arrive wounded from a 2-0 defeat to Bayern Munich last weekend, and not only because of the result.
They lost Daniel Ginczek and Timothy Chandler for the rest of the season due to serious injuries in that game
"It's a shame that we lose two players, especially at this moment of the season, but this is now a chance for other players," said Nurnberg coach Gertjan Verbeek.
"I'm convinced they will take this chance and help us to win."
Nurnberg need the points to stand any chance of moving out of the bottom three this weekend and to bounce straight back from defeat to Bayern in a second straight Bavarian derby.