The Nerazzurri have managed just one win in their previous nine league games, and drew 0-0 against bottom side Catania last time out.
Lack of goals has been Inter's main problem, with Mazzarri's men having found the net just twice in their last six matches.
"We have to help ourselves," Mazzarri said to Gazzetta dello Sport. "We need to play at the same level of our rivals in terms of effort and focus.
"We must find the right solutions because right now we are not comfortable up front.
"I will try to transform this complicated and unpredictable situation that we are in into a positive one.
"There is still time to turn things around and we all believe it can be done."
Rivals Juve were held to a goalless draw by Lazio last weekend to see their 12-game winning run in Serie A come to an end.
The Turin giants will fancy their chances of taking maximum points in the derby d'Italia having won all of their homes matches so far.
Second-placed Roma, who cut Juve's advantage at the summit to six points last weekend, face a big test on Sunday when they take on red-hot Parma at the Stadio Olimpico.
Parma, coached by Roberto Donadoni, are riding a four-match winning streak.
Napoli go into Sunday's match at Atalanta in good spirits after beating Lazio 1-0 in midweek to set up a meeting with Roma in the Coppa Italia semi-finals.
Fiorentina are just three points behind Napoli, who are third and hold the last Champions League qualifying spot.
The Viola visit a Cagliari side that have lost just three times at the Stadio Sant' Elia this term.
Ghana midfielder Michael Essien is expected to make his AC Milan debut in Sunday's home game against Torino, having joined the Rossoneri from Chelsea earlier this week.
Lazio expect to bounce back from their midweek elimination from the Coppa Italia with victory at Chievo.
Genoa have strengthened their defence by signing Marco Motta on loan from Juventus, and the new man should make his debut in Sunday's city derby against Sampdoria.
Bologna and Udinese will battle it out at the Stadio Renato Dall' Ara with both sides looking for their first league win in 2014.
Sassuolo are 18th in the standings with just four wins from 21 games and will be at home to Hellas Verona.
The promoted outfit this week appointed Alberto Malesani as their new coach after dismissing Eusebio Di Francesco.
Finally, bottom side Catania, who clinched their first point away from home this season at Inter last weekend, host Livorno on Sunday.