The attacking midfielder, who turns 22 on Thursday, is the son of former England midfielder Paul Ince who was recently sacked as Blackpool's manager.
He has been linked with a host of clubs, including Swansea and Monaco, and a long-anticipated switch to top-flight league football looks to be imminent.
Blackpool said in a statement on their official website: "Blackpool Football Club can confirm that, following discussions with Thomas Ince and his representative, permission has been given for Thomas to discuss a loan move to a Premier League club.
"Thomas has expressed his ambition to play in the Premier League for the remainder of the season, a decision that the club fully understands and supports."
Ince has made 12 appearances for the England Under-21 side, and is Blackpool's leading scorer with seven goals in the Sky Bet Championship this season.