The midfielder, who cost just short of £21million, only made two appearances during his last stint at Chelsea before heading to Benfica but a potential reappearance is on the cards during the clash with United.
Just two points off top spot, Chelsea will be looking to extend the gap between them and United, who sit in seventh despite winning last weekend.
Matic told chelseafc.com he is relishing the prospect of being managed by Jose Mourinho.
"It's exciting to work with him, he is the best coach in the world and I want to work with him for a long time. I am ready," Matic said.
"I've played regularly in a big club at Benfica, where it is not easy and there is a lot of pressure. In those years I learned to be a winner and play under that pressure.
"I developed tactically in Portugal also, training very hard and I believe I am better physically also."
Leaders Arsenal face Fulham on Saturday with the Gunners looking to extend their four-match winning streak after a 2-1 success on Monday night against Aston Villa.
Playmaker Mesut Ozil, who was named in UEFA's 2013 team of the year, has pinpointed team-mate Tomas Rosicky as a key man for the Gunners, telling arsenal.com: "In my opinion Tomas belongs to the best midfielders in the Premier League.
"When you see how much he gives for the team and how he enjoys being on the ball it makes us happy to have a player like that in our ranks."
With Fulham just one point off the drop zone, Rene Meulensteen's team could be in trouble if results go against them.
Fellow strugglers Cardiff travel to the Etihad Stadium where they take on goal-hungry Manchester City, with the first meeting between the teams this season having seen the Welsh side claim a fine win thanks to a Fraizer Campbell double.
City, who average four goals a game at home, will be aiming to pile pressure on Arsenal at the top and the return of Sergio Aguero from injury boosts their attacking threat.
Liverpool host Aston Villa on Saturday with Luis Suarez aiming to add to his 22 goals from 16 Premier League appearances. A win against Villa would ensure they remain in a Champions League spot.
Elsewhere, Tottenham and Swansea are in action in the early game on Sunday with Spurs summer signing Christian Eriksen having picked up the Danish player of the year award this week.
Eriksen told tottenhamhotspur.com: "I have a lot more to show. I'm lucky I can provide goals and create some chances, but I can still do better and I will work every day to do that."
Newcastle, who have lost their last three Premier League fixtures, go away to West Ham.
Sunderland still sit in the relegation zone and will be desperate for a win at home to Southampton, whose manager Mauricio Pochettino has committed his future to the club despite executive chairman Nicola Cortese's departure.
Bottom side Crystal Palace will have home advantage against 12th-placed Stoke, while Hull and Norwich also do battle and West Brom take on Everton.