City play Liverpool on Boxing Day and Crystal Palace at home on Saturday, while Liverpool are at Chelsea on Sunday and Arsenal play at Newcastle.
"It's not fair, it should be the same for all teams," Pellegrini said.
"I don't know if the word is ridiculous but playing 46 hours from one game to another is not the best thing for the players - they cannot recover in 46 hours.
"All the teams must have the same rest. Arsenal, Tottenham, Chelsea, Liverpool all of them play after (December) 26 and 29. And we play 26 and 28."
The assumption of a team of City's calibre would be that relegation-threatened Palace will be dispatched comfortably.
But first Pellegrini's men put their 100 per cent home record on the line in the ninth Premier League fixture at the Etihad Stadium against Liverpool and Luis Suarez.
Uruguay striker Suarez has netted 19 times in the Premier League this season despite completing his lengthy ban at the start of the campaign.
Yet Pellegrini is adamant the battle with the Reds is about more than one man and City's ability to stop him.
"He is in a very good moment," Pellegrini added.
"He has always been a very good striker. But Liverpool is not only Suarez. They are a very good team, it will be a tough game and we hope we can continue winning at home.
"I repeat we are not playing against Liverpool thinking of Luis Suarez.
"We are playing against Liverpool thinking we must repeat what we are doing at home."
To some, Liverpool are a surprise package in the title race. Not for Pellegrini.
He added: "Every team has the chance to win the Premier League.
"The Premier League is not only Liverpool and Man City, Tottenham will continue fighting.
"Manchester United, Arsenal and Everton are playing good football and will fight for the title until the end."
Pellegrini has already confirmed Joe Hart will continue in goal against the Reds after making his first Premier League start in almost two months in the win at Fulham.
Changes will be expected against Palace, but the priority for the Chilean is Liverpool.
He added: "First of all we have to beat Liverpool, then we see what we will do against Crystal Palace. It's not easy to repeat the same team in 44 hours."