The Scot is set to be in charge of the Welsh club having been given a reprieve of sorts in the wake of owner Vincent Tan's ultimatum that he resign or be sacked.
When releasing a statement saying Mackay would be in charge of the club for the "foreseeable future", chairman Mehmet Dalman had appealed to fans not to display any 'Tan Out' banners at the clash with the Saints, but rather show messages encouraging owner and manager to sort out their differences.
But Mackay, who has been "humbled" by the support he has received from the Bluebirds' faithful, offered no advice to fans, other than to ask them to back his team as they have done throughout the campaign.
"Our fans are the lifeblood of the club," said Mackay.
"When I'm gone and the owner is gone the fans will still be supporting the team. What they want to sing and what they want to say is down to themselves.
"They are intelligent people who have got their own opinions about the football club but I know they will get behind the football team like they have always done from the first day I have arrived there.
"I will always be thankful for that. If they do that then there can be enjoyment of watching their team in the Premier League."
But Mackay insists, despite the upheaval of the past week and his ongoing wait to hold crunch talks with Tan and Dalman, it will be business as usual for his players.
He said: "The players have trained as they always do. We have gone through our structure of a normal day and I have not lost focus.
"We have big games to prepare for and no matter what goes on, that's my number one focus for this club and it always will be."
Cardiff will face a Southampton side whose form has dropped off in recent weeks. The Saints had been in the top four, but a run of six games without a win has dropped them to ninth.
But Mackay expects Mauricio Pochettino's side to hand his side a tough test at Cardiff City Stadium, and pointedly referred to them as an example for the Welsh club to follow.
"Southampton is going to be a tough one," he said. "They are someone I look at and say there is a model which we have been trying to follow this year.
"They came up to the Premier League, they were the best team in the Championship when we played them and they invested well and are trying to do the right things with their football club and with the academy and it can be seen.
"They invested heavily last year and stayed in the league and this summer they invested heavily again and are making a real good way in the Premier League this year."