Two sides keen on a place in the Champions League next season clash at the Borussia Park Stadion, eager to manoeuvre into the best position possible to launch an assault on a top-four finish come May.
Gladbach currently have a three-point advantage over the Wolves, who are fifth, and the chance to open up a six-point gap going into the winter break.
"We want one more great performance, and then we can take a break," said Gladbach coach Lucien Favre, whose side have won all seven games they have played at home this season and are therefore looking to extend that perfect record through to the new year.
"We want to crown a fantastic first half of the season," added the club's director of sport Max Eberl.
The game comes too soon for defender Alvaro Dominguez, whose broken collarbone and dislocated shoulder mean he will not now return until the end of January, when Gladbach host
Bayern Munich in the first game of the second half of the season, perhaps with just nine points between the two clubs.
Wolfsburg would set a new club record first half to a season by picking up a point in Monchengladbach, and extending their eight-game unbeaten streak, although such records do not mean much to coach Dieter Hecking.
"We've played a great half year, but we've not achieved anything yet," he said at a press conference.
"If after 34 games we have played the best ever Bundesliga season in the history of Wolfsburg, then only then will we take that and be happy for it, but there's a long way to go before that can happen."
Hecking can name an unchanged side once again as they bid to move level on points with their hosts.