Supporters must travel to the Amazonian city of Manaus in order to watch their team's opening Group D game against Italy on June 14 - a four-hour flight from Rio de Janeiro.
England boss Roy Hodgson had made no secret of his desire to avoid the venue during the pre-draw build-up, but the Foreign Office's deputy head of Consular Assistance Gavin Cook stressed the city is a welcoming and "adventurous" place with the right preparation.
Cook told Press Association Sport: "What we are concerned about is making sure the fans that go to Brazil have a fantastic time.
"It is a huge country and whichever draw you get is going to present a lot of logistical challenges. Manaus is certainly an adventurous place to get to but it is also a large city with a rich and vibrant culture."
After facing the Italians in Manaus, England go to Sao Paulo four days later to take on Uruguay, before finishing their Group D programme against Costa Rica in Belo Horizonte - scene of their infamous 1-0 defeat to the USA in the 1950 World Cup.
Cook added: "The World Cup will be a fantastic tournament and we expect thousands of fans to go out to support England. Our advice for those people who have not travelled wisely is to think about what you are going to do before you get there, and check the Foreign Office website for updated advice."