The cup holders will make the short trip west, probably without the injured Franck Ribery, bidding to reach the quarter-finals of a competition in which their last defeat came in the 2012 final to Borussia Dortmund.
With a four-point cushion at the top of the Bundesliga and a place already booked in the last 16 of the Champions League, Bayern can afford to focus all of their efforts on victory at the Augsburg Arena to ensure their place in the last eight going into 2014.
And the fact they have an extra day to get the likes of Ribery and Xherdan Shaqiri fit could be a bonus, according to Bayern's director of sport Matthias Sammer.
"It could play into our hands," he said. "But we'll need to be at our very best because Augsburg are a team who clock up some mileage."
The teams met at the same stage of the competition a year ago with Bayern winning 2-0.
Before they meet on Wednesday, perennial rivals Dortmund face a tricky trip to third-division Saarbrucken with an all-Bundesliga clash between Schalke and Hoffenheim the pick of Tuesday night's action.
Hamburg host 2. Bundesliga leaders Cologne while there is an all second-division clash between Union Berlin and Kaiserslautern, ensuring at least one lower-league side will reach the last eight.
On Wednesday, Freiburg, who knocked last year's beaten finalists Stuttgart out in the last round, host high-flying Bayer Leverkusen with Wolfsburg in action against Ingolstadt and, finally, Eintracht Frankfurt hosting SV Sandhausen.