The United States goalkeeper, who will skipper the visitors in the absence of injured striker Clint Dempsey, revealed the Scotland forward has been "chirping" in his ear in the build-up to the match.
Speaking at the national stadium before his side's training session, the Goodison number one admitted that preventing the former Kilmarnock and Rangers player from scoring is at the forefront of his mind.
"We know what they offer in attack and I will certainly do my best to keep Naisy out as I will never hear the end of it," he said.
"He has spoken to me about the game, he has been chirping in my ear for the last two or three weeks but I have kept quiet.
"They are dangerous, certainly, we will have our work cut out.
"Steven Fletcher is a natural goal scorer, he just gets himself in the right positions.
"Robert Snodgrass is tricky, the way he hits the ball means that as a goalkeeper you always have to be on your mettle.
"So we know what they offer and we know what to expect. They are a hard-working side and they don't roll over easily.
"It will be very difficult for us, they are going to make it hard as it is on their own turf."
USA boss Jurgen Klinsmann, whose side will also play Austria in Vienna next week in preparation for the 2014 World Cup finals in Brazil, insists his team will get the proper "test" they need as they prepare for next summer.
"We wanted to go to Europe specifically and prove a point, that we want to compete one day with the best in the world," he said.
"It will take some a while to get there but we are going through a process of improvement.
"This game is going to be a benchmark for a team trying to do better.
"It is part of a learning process and we are looking forward to it."
The former Germany striker and manager is disappointed that the Scots will not be joining the Americans in Brazil.
"It is sad to see that Scotland didn't qualify because everybody wants to see Scotland in the World Cup, also because of their fantastic fans," he said.
"They are known world wide.
"When you think of Scottish football, you think of the passion and players dedicated to the team with work-rate and individual talent.
"They are always emotional, they give you everything they have, so it is a good benchmark."
Klinsmann's wariness of his side's task in Glasgow could be taken as a platitude given that the USA beat Scotland 5-1 in their post-season friendly match in Jacksonville in 2012.
However, the former Inter Milan, Bayern Munich and Tottenham striker said: "It is a completely different game and we are well aware of that.
"Scotland did us a favour coming over after their season was over, in 95 degrees, and we knew it was going to be very difficult for us.
"We were on a totally different page then. We know that Scotland in any given moment, can score and can beat us.
"So we are going to be very alert."
On Dempsey's calf injury, Klinsmann said: It is a big bummer for us. He is the leader in our group.
"What he has done in the last couple of years for us has been priceless.
"To see him limping off was a real shock to us because he was really hungry for the two friendlies."