The two clubs have drawn more than anybody else in the German top flight, Nuremberg taking a single point on seven occasion while Freiburg have avoided defeat in half of their first 10 games this season.
The points are not getting either club very far, though, which is why both are keen to secure victory this weekend.
"We need to win," said Nuremberg coach Gertjan Verbeek, who makes his home debut this weekend having drawn at Stuttgart in his first match in charge.
"The fans are going to be an extra motivation for us and I hope that they help us."
Freiburg coach Christian Streich acknowledged the fact that his opponents, in spite of their winless streak, are one of the toughest to beat in the Bundesliga.
"They've not won, like us, but they've only lost three and not many clubs have a better record than that," Streich said.
"They've got a good team with Makoto Hasebe and Hiroshi Kiyotake, two excellent footballers in the middle.
"They're aggressive, but they also have some good technical quality.
"We've got to find stability and the right balance in our play."
Streich has an injury concern with Vladimir Darida bruising his foot in training on Thursday and he may not be available to make his second consecutive Bundesliga appearance.
Verbeek has no such problems for his second game in charge, saying: "All my players are healthy, which is nice."