City were extended both physically and emotionally in their Champions League clash with CSKA Moscow in midweek.
Manuel Pellegrini's men emerged victorious - a vital 2-1 win putting them in sight of the knockout stages - but physically weary after being extended on a poor pitch.
Then there was also the emotional toll from the racism controversy which marred the contest, City talisman Yaya Toure having complained that he was the target of monkey taunts from the crowd.
They must put all that behind them as they continue their energy-sapping week - which began at West Ham last Saturday - with another away trip, this time to Stamford Bridge, on Sunday.
Toure is likely to be at the forefront of their challenge and wants to channel the positives from the midweek game to refocus on Chelsea.
The 30-year-old said: "I think the lads played very well and tried hard to win.
"It is very important to go with this confidence against Chelsea.
"Chelsea are a big rival and an important club as well. I hope we can win this game."
There is just a point between second-placed Chelsea and City, in fourth, in the Barclays Premier League.
City's line is again likely to be led by Sergio Aguero, who continued his hot run of form with the two goals that saw them come from behind in Moscow.
The Argentinian was also on target twice against West Ham and has scored eight in his last six games, nine overall this season.
Toure said: "I hope he continues in this form, he and (David) Silva, (Alvaro) Negredo, (Jesus) Navas.
"Samir (Nasri) is to come in, and (Edin) Dzeko. We have fantastic strikers and we are very strong.
"I hope the strikers continue to do the job they are doing."
Aguero's partnership with Negredo is growing in strength and the pair seem manager Manuel Pellegrini's current first choice up front.
They could well start again with changes far more likely for next Wednesday's Capital One Cup trip - a fourth successive away game - to Newcastle.
Captain Vincent Kompany has been the main doubt after two games out with a groin injury but Pellegrini has said he is fit and back in contention.