Starting the season with the aim of establishing themselves in mid-table, Hoffenheim knew that the likes of Borussia Dortmund, Bayern Munich and
Bayer Leverkusen would be the untouchables in the Bundesliga.
Calculating that there would be no points available from any of the six meetings with the "top three teams in Germany", Gisdol says his side can therefore be relaxed about Friday night's home game and treat it like an extra chance.
"It's a bonus game because hardly anybody expects us to get any points from it," he said at a press conference.
"But of course we will do all we can on the field to get something."
Everything they can give and nothing less will be required to pick up one - or more - unexpected point.
"We're going to have to have a really top day if we want to get anything because, without that, we're not going to get anything," added Gisdol.
"Bayer have established themselves in the top three of German football over the years and they have huge quality, particularly up front with (Sidney) Sam, Son (Heung-min) and (Stefan) Kiessling."
That trio has 12 goals between them so far this season, making them the fiercest attack in the division.
Pitted against the leakiest defence - Hoffenheim have conceded 20 while also scoring 20 in eight games so far - goals seem likely at the Rhein-Neckar Arena.
There was some fear that Kiessling may not be available due to a foot injury, but the 29-year-old has returned to training and is fit to play.
Coach Sami Hyypia may nevertheless rest one of his front three and give Robbie Kruse a start in view of the Champions League tie with Shakhtar Donetsk on Wednesday.