Their opponents are already planning for Brazil but for Uruguay it remains to be seen whether or not they will qualify automatically in fourth or face a play-off against Jordan.
To avoid a two-legged play-off, Uruguay must hope that the Chile v Ecaudor clash is not a draw and that they can beat Argentina with a sizeable goal difference swing.
In all probability with Chile and Ecuador facing each other and both needing a point to go through, Uruguay will be playing Jordan.
"Argentina are a world football power, arch rivals of us and whatever will happen in that game will be very important for the future," told the media, extremely aware of the need to stay in form ahead of the play-offs.
Diego Forlan, though, thinks there is still a chance of avoiding a play-off.
"We still have a little chance, although we all know it is not easy," the former Manchester United striker told Argentinian channel TyC Sports.
"We are full of expectation to play Argentina. The important thing is to be in the World Cup, no matter how."
"People thought the fact of Brazil not playing the qualifying tournament would make it easier for Uruguay, but we had the experience that it was not going to be that easy."
Argentina head into this game after a 3-1 home win over Peru and, as well injured duo Lionel Messi and Gonzalo Higuain missing this match, coach Alejandro Sabella will also make Sergio Aguero and Angel Di Maria rest.
Also, Newcastle defender Fabricio Coloccini was released with a minor muscular injury, while Tottenham playmaker Erik Lamela is reportedly in line to start.
But Tabarez does not believe the Argentina match will be easier despite the absentees.
"Argentina have their own way to play, their own style," he said.
"Against Peru, with several changes, showed the same style. That makes it very difficult to us, but we are focused on winning," he said.
Meanwhile, Lamela is looking forward to a starting opportunity to try and impress and earn a place in the 23-man World Cup squad.
"I hope I can finally have the chance and do my best to help the team. I always try to do my best," Lamela told Ole newspaper.
"I'd love to play the World Cup. That is why this is a chance I have to take."