With qualification for Brazil already in the bag, the match will have no impact, especially as Peru are out of the running to make it.
With a number of key starters such as Lionel Messi, Fernando Gago, Javier Mascherano and Ricky Alvarez not selected due to injury, and Gonzalo Higuain banned, the chance has presented itself for Sabella to tinker.
He is willing to take it too, saying: "This is a nice chance to integrate other players. That is good for us, despite nobody liking to be injured..
"We have lost some crucial members. It is always a problem when Messi does not play. He is irreplaceable. When he is not on the field history changes for us and our rivals. It is a challenge for me to find solutions with him away."
Peru coach Sergio Markarian also has things to ponder.
He too is likely to make changes, with the 2018 World Cup on his mind.
"There are a lot of youngsters that will take part in the next qualification process ahead of a World Cup and it is time for them to have their first minutes on the pitch," he said.
"I am responsible for the starting XI and I hope they can prove me right, despite their age."
Argentina are the sole leaders of the South American group on 29 points, with Peru some way down with 14.