Shandong's only hope of denying Marcello Lippi's men the impressive treble, or at least of denying them the trophy for another week, was to close the gap to eight points with victory on home turf on Sunday afternoon.
Gilberto Macena did cancel out Zhao Xuri's sixth-minute opener for the visitors but Guangzhou streaked clear through Rong Hao (39), Gao Lin (45) and Zheng Zhi (64) before Roda Antar pulled a goal back 13 minutes from time.
Guangzhou, who are now preparing to face FC Seoul in the two-legged AFC Champions League final, become the first side to win three consecutive Chinese titles since Dalian Shide achieved the feat in 2002.
Shanghai Shenhua were stripped of the 2003 title for match-fixing and have not enjoyed the current campaign, but moved into sixth place with a 2-1 home win over Guizhou Renhe.
The capital club had to do things the hard way, however, coming from behind with a late brace of penalties from Firas Al Khatib (75 and 83) after Rolando Schiavi's 35th-minute own goal had put fourth-placed Guizhou on the front foot.